反应详情

To a mixture of 4,4,4-trifluoro-1-[4-(methylthio)phenyl]butane-1,3-dione (5 g) and 2-methyl-2-thiopseudourea sulfate (5.1 g, 0.98 eq) in acetic acid (100 ml) was added sodium acetate (3 g, 2 eq) and heated under reflux for 8 h. The mixture was concentrated in vacuo and water (100 ml) added to give a solid, which was isolated by filtration to give the title compound as a yellow solid (5.8 g, quantitative).

1. temperatureheated
2. temperatureunder reflux for 8 h
3. concentrationThe mixture was concentrated in vacuo and water (100 ml)
4. additionadded
5. customto give a solid
6. customwhich was isolated by filtration