HCID 22184678, compound → HCID 22184671, compound

Participants

Reaction Steps

To a solution of 15.5 g (54 mmol) of the alcohol from Step B in dichloromethane was added 20 g of Celite and 17.5 g (81 mmol) of pyridinium chlorochromate. The reaction mixture was stirred at room temperature for a 4 h period, and then filtered. The solids were washed with dichloromethane and the combined organic phases were concentrated. The residue was purified by flash chromatography on silica gel (15% ethyl acetate/hexane) to give 13 g (85%) of the title compound. 1H NMR (500 MHz, CDCl3) δ 3.63 (d, 2H, J=4.9 Hz), 2.49–2.32 (m, 4H), 2.12 (m, 2H), 1.96 (m, 1H), 1.49 (m, 2H) 1.07 (d, 18H, J=5.5 hz), 1.06 (m, 3H).

Provenance & Evidence