HCID 86759970, compound → HCID 22184672, compound

Participants

Reaction Steps

A mixture of 10.3 g (30.2 mmol) of the unsaturated ester from Step D and 600 mg of 5% palladium on carbon in 150 mL of methanol was stiffed under an atmosphere of hydrogen for 3 h. The catalyst was filtered off and the filtrate concentrated to give 8.8 g (85%) of the title compound as a mixture of cis and trans isomers. 1H NMR (500 MHz, CDCl3) δ 3.68 (s, 3H), 3.57 (d, 0.6H, J=6.7 Hz), 3.39 (d, 1.4H, J=6.2 Hz), 2.32 (d, 0.6H, J=4.4 Hz), 2.21 (d, 1.4H, J=3.9 Hz), 1.82–1.60 (m, 4H), 1.54 (m, 1H), 1.45 (m, 1H), 1.1–1.05 (m, 21H), 1.01 (m, 2H).

Provenance & Evidence