Triethylamine → HCID 22184675, compound

Participants

Reaction Steps

The acid (8.5 g, 25.9 mmol) from step F was treated with 3.14 g (3.2 mL, 26 mmol) of pivaloyl chloride and 10.5 g (14.5 mL, 26 mmol) of triethylamine followed by 1.32 g (28 mmol) of lithium chloride and 4.60 g (26 mmol) of 4-phenylmethyl-2-oxazolidinone according to the procedure of G.-J. Ho and D. J. Mathre, J. Org. Chem. 1995, 60, 2271–2273 to provide, after purification by flash chromatography on silica gel (10% ethyl acetate/hexane), 11.5 g (91%) of the title compound. 1H NMR (500 MHz, CDCl3) δ 7.32 (m, 2H), 7.27 (m, 1H), 7.23 (d, 2H, J=6.9 Hz), 5.31 (m, 1H),

Provenance & Evidence