反应详情

A solution of 4-(trifluoromethyl)benzenesulphonyl chloride (2.4 g, 9.84 mmol) in pyridine (40 mL) is cooled to 0° C. Salicylaldehyde (1.44 g, 11.8 mmol) is added and stirred overnight. Water and ethyl acetate are added to the reaction and shaken. The organic layer is washed with dilute HCl (0.1 N×2), H2O, bicarbonate solution, H2O and dried with sodium sulfate. The organic layer is evaporated to dryness to give a yellow solid, which is recrystallized from ether/hexane to give 2-formylphenyl 4-(trifluoromethyl)benzenesulfonate as a yellow powder (1.70 g, 52%).

1. stirringshaken
2. washThe organic layer is washed with dilute HCl (0.1 N×2), H2O, bicarbonate solution, H2O
3. dry with materialdried with sodium sulfate
4. customThe organic layer is evaporated to dryness
5. customto give a yellow solid, which
6. customis recrystallized from ether/hexane