反应详情

A solution of 2-formylphenyl 4-(trifluoromethyl)benzenesulfonate (1.7 g, 5.1 mmol) in warm ethanol (100 mL) is added dropwise over 1 hour into a solution of hydrazine (6 equiv) in ethanol (5 mL). The reaction is stirred at room temperature overnight at which time the solvent is evaporated to dryness. The crude product is recrystallized from CH2Cl2/hexane to remove a dimer by-product. An 89% yield of 2-[hydrazonomethyl]phenyl 4-(trifluoromethyl)benzenesulfonate (4.65 g) is obtained.

1. customis evaporated to dryness
2. customThe crude product is recrystallized from CH2Cl2/hexane
3. customto remove a dimer by-product