Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 178499561 | HCID 178499561 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178514425 | HCID 178514425 | — |
Reaction Steps
To a solution of 4-imidazoleacetic acid methyl ester hydrochloride (3.95 g, 22.4 mmol) in ethanol (150 ml) is added N,N-diisopropylethylamine (2.90 g, 16.6 mmol) and hydrazine (1.79 g, 36 mmol). The solution is refluxed at 70° C. overnight. The solution is concentrated and recrystallized from methanol to give 4-imidazoleacetic acid hydrazide as a white solid. The yield is 2.46 g, 78%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07026339B2 |
|---|
| Source dataset | uspto-grants-2006_04 |
|---|
| ORD ID | ord-159ec25e35cc46d8bb7781458ec342b9 |
|---|
| Source note | uspto-grants-2006_04 |
|---|
