Benzeneacetic acid, hydrazide → HCID 16075309, compound

Participants

Reaction Steps

To a solution of-phenylacetic acid hydrazide (0.24 mmol) in absolute EtOH 10 mL and acetic acid 0.4 mL is added 2-{[(4-methylphenyl)sulfonyl]methyl}benzaldehyde (0.22 mmol). The reaction is stirred at room temperate for 2.5 hr with white ppt formation. The reaction mixture is then filtered. The solid is triturated with MeOH to give N′-[(1E)-(2-{[(4-methylphenyl)sulfonyl]methyl}phenyl)methylene]-2-phenylacetohydrazide in 78% yield. 1H NMR (400 MHz, DMSO-d6) □ 11.50–11.25 (2s, 1H), 8.22–8.13 (2s, 1H), 7.79 (m, 1H), 7.56 (m, 2H), 7.31 (m, 10H), 4.93–4.80 (2s, 2H), 3.95–3.57 (2s, 2H), 2.36–2.31 (2s, 3H). ESI− for C23H22N2O3S, m/z 405 (M−H)−.

Provenance & Evidence