Benzeneacetic acid, hydrazide → HCID 16075311, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4-methylphenoxy)-benzaldehyde (500 mg, 2.36 mmol) in EtOH (10 mL) is added phenyl acetic hydrazide (336 mg, 2.36 mmol) and the reaction is heated to 80° C. for 1 h. While cooling a white precipitate forms, and this solid is isolated by filtration and washed with portions of EtOH and Et2O. This solid is dried under vacuum to provide N′-{(1E)-[2-(4-methylphenoxy)phenyl]methylene)}2-phenylacetohydrazide (432 mg, 22%). 1H-NMR (400 MHz, DMSO-d6) 11.70–11.55 (m, 1H), 8.51–8.33 (m, 1H), 8.00–7.92 (m, 1H), 7.42–7.19 (m, 9H), 6.91–6.85 (m, 3H), 3.98–3.43 (m, 2H), 2.29 (s, 3H). ESI+ for C22H20N2O2: m/z=345 (M+H)+.

Provenance & Evidence