反应详情

温度

135 °C

A mixture of 2-vinylphenyl 4-(trifluoromethyl)benzenesulfonate (1.8 g, 5.5 mmol) and ethyl diazoacetate (0.70 mL, 6.7 mmol) under argon is heated at 135° C. for 90 min. The product is purified on silica gel in methylene chloride and ethyl acetate-methylene chloride mixtures. The product, ethyl 2-[2-({[4-(trifluoromethyl)phenyl]sulfonyl}oxy)phenyl]cyclopropanecarboxylate, is obtained as a mixture of isomers. A yield of 50% is obtained.

1. customThe product is purified on silica gel in methylene chloride and ethyl acetate-methylene chloride mixtures