HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [(Pyridin-4-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Chloromethyl)pyridine | HCID 74571 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [(Pyridin-4-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile | HCID 22185754 | 79.8% |
Reaction Steps
By using (3,3,3-trifluoropropyl)malononitrile (401 mg), N,N-dimethylformamide (6 ml), potassium carbonate (0.68 g) and 4-(chloromethyl)pyridine (406 mg) according to the similar method described in Production Example 4 was obtained 500 mg of 2-(4-pyridylmethyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (7)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026340B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-2f394b75f0f841149e62515174412c95 |
| Source note | uspto-grants-2006_04 |