HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [(6-Chloropyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Bromomethyl)-6-chloro-pyridine | HCID 22032737 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [(6-Chloropyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile | HCID 22185763 | 91% |
Reaction Steps
By using (3,3,3-trifluoropropyl)malononitrile (226 mg), N,N-dimethylformamide (5 ml), potassium carbonate (193 mg) and 2-(bromomethyl)-6-chloropyridine (335 mg) according to the similar method described in Production Example 4 was obtained 365 mg of 2-((6-chloro-2-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (the present invention compound (8)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026340B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-0502bdb8c5b34c19a8fc6087d5105681 |
| Source note | uspto-grants-2006_04 |