Trifluoroacetic acid → HCID 22185381, compound

Participants

Reaction Steps

A solution of Example 1 (112 mg, 0.245 mmol) in dichloromethane (2 ml) containing trifluoroacetic acid (1 ml) was stirred at room temperature for 3 hours. The solution was concentrated at reduced pressure and the residue was partitioned between saturated sodium hydrogen carbonate solution and ethyl acetate. The organic layers were then combined, washed with brine, dried over anhydrous magnesium sulphate, filtered and concentrated at reduced pressure to give the title compound (59 mg, 68%) as a solid; MS(ES+) m/e 357/359 [M+H]+.

Provenance & Evidence