Hydrochloric Acid → HCID 69585166, compound

Participants

Reaction Steps

To solution of (R)-3-(5-tert-butoxycarbonylamino-2-chlorophenoxy)-pyrrolidine-1-carboxylic acid-tert-butyl ester (2 g, 4.9 mmol) in dioxane (30 mL) was added 6 N hydrogen chloride (20 mL). The reaction mixture was stirred for 2 hours, at which time it was concentrated. The resultant residue was triturated with ethyl acetate and dichloromethane, the diluted with 2.5 M potassium hydroxide (50 mL) and extracted with dichloromethane (3×50 mL). The combined organics were washed with brine (50 mL), dried over magnesium sulfate, and concentrated to give (R)-3-(5-amino-2-chlorophenoxy)-pyrrolidine (810 mg, 75%).

Provenance & Evidence