HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2-(1H-Tetrazol-1-YL)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 2-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid | HCID 753608 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(1H-Tetrazol-1-YL)benzamide | HCID 855956 | — |
Reaction Steps
A solution of 2-tetrazol-1-yl-benzoic acid (1.0 g, 5.2 mmol), ammonium chloride (0.56 g, 10.4 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.0 g, 10.4 mmol), 1-hydroxy-7-azabenzotriazole (1.4 g, 10.4 mmol) and diisopropylethylamine (3.6 ml, 20.8 mmol) in N,N-dimethylformamide (15 ml) was stirred at room temperature overnight. Water was added and the reaction mixture was extracted with ethyl acetate. The combined organic layers were washed with brine. Drying and solvent evaporation gave 2-tetrazol-1-yl-benzamide; 1H NMR (CD3OD, 400 MHz) δ 9.44 (s, 1H), 7.72 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026324B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-1fdba3ae423d4c1980ae4fa93598f0e0 |
| Source note | uspto-grants-2006_04 |