反应详情

2-(1,2,4-Triazol-4-yl)cyanobenzene (0.3 g; 1.76 mmol) from step A of example 9 was combined with 30% by weight of palladium on carbon, 10% catalyst (100 mg) in ethanol (75 ml) and placed on a PARR hydrogenation apparatus under a hydrogen atmosphere at 55 psi. for 48 hours. The mixture was filtered through celite and concentrated to give 2-(1,2,4-triazol-4-yl)benzylamine; 1H NMR (CD3OD) δ 8.77 (s, 2H), 7.69–7.59 (m, 4H), 3.61 (s, 2H).

1. filtrationThe mixture was filtered through celite and
2. concentrationconcentrated