1-Phenethylamine, (-)- → HCID 21023644, compound

Participants

Reaction Conditions

Reaction Steps

To a 100 mL RBF, was added 6-(2-chloro-pyridin-4-yl)-2-(2-methoxymethyl-pyrrolidin-1-yl)-3-methyl-5-m-tolyl-3H-pyrimidin-4-one (0.3 g, 0.71 mmol), 50 mL toluene, and (S)-α-methyl benzylamine (0.181 mL, 1.42 mmol). The mixture was degassed by nitrogen bubbled through for 1 h. After added Pd(OAc)2 (24 mg, 0.106 mmol), BINAP (65 mg, 0.106 mmol) and NaOtBu (0.191 g, 2.0 mmol), the mixture was warmed up to 100° C. and stirred for 3 h under nitrogen. The mixture was cooled down to rt, and vacuumed down all volatile composites. After purified by flash chromatography, the title compound was obtained in 0.18 g as pale yellow solid. MS (ES+): 510 (M+H)+.

Provenance & Evidence