Sodium Hydroxide → HCID 23694499, compound
Reaction equation
[OH-:1].[Na+:2].[CH3:3][C:4]1([CH3:9])[O:7][C:6](=[O:8])[CH2:5]1>O>[OH:7][C:4]([CH3:9])([CH3:3])[CH2:5][C:6]([O-:1])=[O:8].[Na+:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of sodium hydroxide (127.3 g; 3.15 mol) in water (1.5 l) was cooled to 0° C. Then, crude 4,4-dimethyloxetan-2-one (=β-isovalerolactone; 336.7 g; 3 mol; obtained by reacting ketene with acetone) was added dropwise in the course of approximately 2¼ h with vigorous stirring, with the temperature being kept from 1.5 to 2° C. The reaction mixture was stirred for a further 15 min at 0° C. and then heated for a further 40 min at 22° C. Then 415 g of water were distilled off at 300 mbar in the course of approximately 3 h. In this manner 1533 g of a solution containing approximately 27.5% by weight of sodium 3-hydroxy-3-methylbutyrate were obtained.
Workup
- custombeing kept from 1.5 to 2° C
- temperatureheated for a further 40 min at 22° C
- distillationThen 415 g of water were distilled off at 300 mbar in the course of approximately 3 h
- additionIn this manner 1533 g of a solution containing approximately 27.5% by weight of sodium 3-hydroxy-3-methylbutyrate
- customwere obtained
Sources & evidence
- ORD record
- ord-72035b6b43ec430d81d06204c1f3bba6
- Source dataset
- uspto-grants-2006_04
- Patent number
- US07026507B2
Reaction notes
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