HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzoyl chloride → N-(2,6-difluorobenzoyl)-L-tyrosine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| Reactant | Tyrosine ethyl ester hydrochloride | HCID 2724939 | — |
| Product | N-(2,6-difluorobenzoyl)-L-tyrosine ethyl ester | HCID 66843057 | — |
Reaction Steps
L-Tyrosine ethyl ester hydrochloride (10.0 g) was acylated with 2,6-difluorobenzoyl chloride in a similar manner as described in Example 1-(5) to give N-(2,6-difluorobenzoyl)-L-tyrosine ethyl ester (13.2 g). mp. 149-150° C.; IR (Nujol) 3424, 3277, 1721, 1660, 1624 cm−1; MS (APCI) m/z 350 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026501B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-41fc3fa28e164325962a0a34172c59b2 |
| Source note | uspto-grants-2006_04 |