HCID 12088903, compound → 4-Isopropyl-6-methoxy-1,1,7-trimethyl-1,2-dihydronaphthalene

HRID 1795580Notes

Reaction equation

HRID 1795580 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:15])([CH3:14])[CH2:8][CH2:9][C:10]2=O)=[CH:5][C:4]=1[CH3:16].[CH:17]([Mg]Cl)([CH3:19])[CH3:18]>>[CH:17]([C:10]1[C:11]2[C:6](=[CH:5][C:4]([CH3:16])=[C:3]([O:2][CH3:1])[CH:12]=2)[C:7]([CH3:15])([CH3:14])[CH2:8][CH:9]=1)([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 12088903HCID 12088903, compound2×HCID 178418918HCID 178418918, compound

Product 1

HCID 222182254-Isopropyl-6-methoxy-1,1,7-trimethyl-1,2-dihydronaphthaleneYield 100%

Procedure

Following General Procedure A, 7-methoxy4,4,6-trimethyl-3,4-dihydro-2H-naphthalen-1-one (Compound 6, 1.0 g, 4.6 mmol) was reacted with a solution of 2 M isopropylmagnesium chloride (12 mL, 22.9 mmol) to give 1.1 g (100%) of the title product as a yellow oil.

Sources & evidence

ORD record
ord-13b49989cbb24ab3ab018be65c59a196
Source dataset
uspto-grants-2006_04
Patent number
US07026487B2

Reaction notes

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