Acetaldehyde → HCID 9947152, compound

HRID 1795584Notes

Reaction equation

[C:1]([C:5]1[C:14]2[CH:13]=[C:12]([NH:15][C:16]3[CH:26]=[CH:25][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:18][CH:17]=3)[C:11]([CH3:27])=[CH:10][C:9]=2[C:8]([CH3:29])([CH3:28])[CH2:7][CH:6]=1)(C)(C)[CH3:2].C(=O)C>>[CH2:1]([C:5]1[C:14]2[CH:13]=[C:12]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:25][CH:26]=3)[C:11]([CH3:27])=[CH:10][C:9]=2[C:8]([CH3:29])([CH3:28])[CH2:7][CH:6]=1)[CH3:2]

Participants

Reactant 2

HCID 177Acetaldehyde

HCID 10293873HCID 10293873, compound2×

Product 1

HCID 9947152HCID 9947152, compoundYield 89.2%

Procedure

Following General Procedure D, ethyl 4-[(8-tert-butyl-3,5,5-trimethyl-5,6-dihydronaphthalen-2yl)amino]benzoate (Compound 18, 0.14 g, 0.37 mmol) was reacted with acetaldehyde (0.40 mL, 7.4 mmol) to give 0.12 g (75%) of the title compound as a light yellow solid.

Sources & evidence

ORD record: ord-05ef23172686452d9f044c79e74d914a
Source dataset: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07026487B2

Reaction notes

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