Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | HCID 22218281 | HCID 22218281 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 22218226 | HCID 22218226 | — |
Reaction Steps
A mixture of ethyl 4-(8-t-butyl-5,5-dimethyl-5,6-dihydronaphthalen-2-ylamino)-benzoate (Compound 84, 170 mg, 0.45 mmol), K2CO3 (900 mg), allyl bromide (1 mL) and dimethylacetamide (5 mL) was heated to 75° C. in a sealed tube for 7 days. The mixture was diluted with ether (70 mL), washed with brine, dried and the solvent was removed. Silica gel flash chromatography gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07026487B2 |
|---|
| Source dataset | uspto-grants-2006_04 |
|---|
| ORD ID | ord-088e0dff51a448ba92a31da744a6bb3d |
|---|
| Source note | uspto-grants-2006_04 |
|---|
