HCID 69659075, compound → HCID 22218208, compound

HRID 1795623Notes

Reaction equation

HRID 1795623 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[CH:5]([C:6]([CH3:14])([CH3:13])[CH2:7][CH2:8][C:9]2=O)[CH2:4][C:3]=1[O:15][CH3:16].[C:17]([Mg]Cl)([CH3:20])([CH3:19])[CH3:18]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5](=[CH:4][C:3]=1[O:15][CH3:16])[C:6]([CH3:14])([CH3:13])[CH2:7][CH:8]=[C:9]2[C:17]([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 69659075HCID 69659075, compound2×HCID 178418310HCID 178418310, compound

Product 1

HCID 22218208HCID 22218208, compoundYield 34%

Procedure

Following General Procedure A, 7-bromo-6-methoxy-4,4-dimethyl-dihydro-2H-naphthalen-1-one (Compound 92, 1.5 g, 5.3 mmol) was reacted with t-butylmagnesium chloride to afford 0.5743 g (34%) of the title compound as a yellow oil.

Sources & evidence

ORD record
ord-5ec762a0c06a47ada97e324500aca1d0
Source dataset
uspto-grants-2006_04
Patent number
US07026487B2

Reaction notes

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