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HRID1795723

反应详情

EQUATION

反应方程式

HRID 1795723 的结构方程式

REACTANTS

反应物

1
结构：CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O.Cl
HCID6420023

Vancomycin monohydrochloride

C66H76Cl3N9O24

2 次

PRODUCTS

生成物

1
结构：CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O
HCID14969

Vancomycin

C66H75Cl2N9O24

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

结构：O
溶剂HCID962

Water

H2O

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

In this formulation, 1.0 g PLGA 50:50 RG 502 H was dissolved in 20 ml of methylene chloride, yielding a 3.33% w/v solution of the base polymer. Then, 0.20 g of Fe3O4 (8.47% w/w of the total) was blended, and 1.0 g of FAO was dissolved in 10 ml of acetone and blended at a loading of 43.67% w/w of the total. Vancomycin HCl (Sigma) was dispersed into the mixture by adding 0.4 ml of 227.3 mg/ml Vancomycin HCl in distilled water to 30 ml of polymer solution. The mixture was emulsified, frozen, and lyophilized as in Example 7. The resulting composition of the dry solids is shown in Table 16.

WORKUP

后处理

  1. customyielding a 3.33% w/v solution of the base polymer
  2. temperaturefrozen