反应详情

16.25 g (86 mmol) of 8-hydroxy-5-quinolinecarboxylic acid were dissolved in 70 ml of methanol, 3 ml of concentrated sulfuric acid were added and the mixture was heated under reflux for 25 hours. The solvent was then removed and the residue was taken up in ice-water, adjusted to a pH of 8 using sodium carbonate solution and filtered hot. The residue was extracted with methyl-tert-butyl ether for 7 hours on a jacketed Soxhlet extractor, and the solvent was subsequently removed from the extract. This gave 6.8 g of a brown powder;

1. temperaturethe mixture was heated
2. temperatureunder reflux for 25 hours
3. customThe solvent was then removed
4. filtrationfiltered hot
5. extractionThe residue was extracted with methyl-tert-butyl ether for 7 hours on a jacketed Soxhlet extractor
6. customthe solvent was subsequently removed from the extract