4-Nitrophenol → HCID 131723614, compound

Participants

Reaction Steps

Compound (xi) was treated with 4-nitrophenol according to the procedure described in Example 1, step 4. The crude product was purified by flash chromatography (elution with chloroform:methanol:concentrated ammonium hydroxide; 8:2:0.25) to afford the ammonium salt 47 (43%) as a colorless solid: 1H NMR (400 MHz, CD3OD) δH 8.19–8.23 (m, 2 H, Ar—H), 7.85 (dd, J=1, 5 Hz, 1 H, Ar—H), 7.62 (dd, J=1, 4 Hz, 1 H, Ar—H), 7.44 (dd, J=1, 9.5 Hz, 2 H, Ar—H), 7.23 (dd, J=4, 5 Hz, 1 H, Ar—H), 3.30 (d, J−13.5 Hz, 2 H, NCH2P), 2.93 (s, 3 H, NCH3); 13C NMR (100 MHz, CD3OD) δC 37.1, 47.4, 122.4 (d, J=4 Hz), 126.1, 128.9, 133.7 (d, J=7 Hz), 137.1, 144.7, 159.5; 31P NMR (162 MHz, CD3OD) δP 12.7; MS (neg. FAB) m/z 391 (M−1, 100%), 306 (15%), 153 (35%).

Provenance & Evidence