3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → HCID 22179339, compound

HRID 1795814Notes

Reaction equation

HRID 1795814 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[CH2:6][N:7]1[CH2:14][CH2:13][CH2:12][O:11][C:10]2[N:15]=[C:16](Cl)[CH:17]=[C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]=2[C:8]1=[O:26].C(O[C:41]([N:43]([CH:45]1[CH2:49][CH2:48][NH:47][CH2:46]1)C)=O)(C)(C)C>>[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[CH2:6][N:7]1[CH2:14][CH2:13][CH2:12][O:11][C:10]2[N:15]=[C:16]([N:47]3[CH2:48][CH2:49][CH:45]([NH:43][CH3:41])[CH2:46]3)[CH:17]=[C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]=2[C:8]1=[O:26]

Participants

3

Reactant 2

HCID 27614043-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidineHCID 221793335-[3,5-bis(trifluoromethyl)benzyl]-9-chloro-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

Product 1

HCID 22179339HCID 22179339, compoundYield 50.1%

Procedure

In a similar manner to Example 11, 5-[3,5-bis(trifluoromethyl)benzyl]-9-chloro-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (40.0 mg) was reacted with 3-(N-(t-butoxycarbonyl)-N-methylamino)pyrrolidine (38.9 mg) to obtain 5-[3,5-bis(trifluoromethyl)benzyl]-9-[3-(methylamino)pyrrolidine-1-yl]-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (22.5 mg, 50%).

Sources & evidence

ORD record
ord-587ab5837f90480abf3c222acf9b5b8e
Source dataset
uspto-grants-2006_04
Patent number
US07030107B2

Reaction notes

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