HRID1795818

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18314250

1-(Piperidin-4-yl)pyrrolidin-2-one

C9H16N2O

结构：O=C1c2c(-c3ccc(F)cc3)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID22179324

未命名化合物

PRODUCTS

生成物

结构：O=C1c2c(-c3ccc(F)cc3)cc(N3CCC(N4CCCC4=O)CC3)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID22179327

未命名化合物

收率 39.3%

PROCEDURE

实验过程

In a similar manner to Example 1, 5-[3,5-bis(trifluoromethyl)benzyl]-9-chloro-7-(4-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (53.3 mg) was reacted with 4-(2-oxopyrrolidine-1-yl)piperidine (20.2 mg) to obtain 5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-6-oxo-9-[4-(2-oxopyrrolidine-1-yl)piperidine-1-yl]-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (26.1 mg, 39%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-64d075246d224bd7bd138deef34f3b02
来源数据集: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07030107B2
来源说明: uspto-grants-2006_04

反应 SMILES

[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]1[CH2:14][CH2:13][CH2:12][O:11][C:10]2[N:15]=[C:16](Cl)[CH:17]=[C:18]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:9]=2[C:8]1=[O:27].[O:37]=[C:38]1[CH2:42][CH2:41][CH2:40][N:39]1[CH:43]1[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]1>>[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]1[CH2:14][CH2:13][CH2:12][O:11][C:10]2[N:15]=[C:16]([N:46]3[CH2:45][CH2:44][CH:43]([N:39]4[CH2:40][CH2:41][CH2:42][C:38]4=[O:37])[CH2:48][CH2:47]3)[CH:17]=[C:18]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:9]=2[C:8]1=[O:27]