1-(Piperidin-4-yl)pyrrolidin-2-one → HCID 22179328, compound

HRID 1795822Notes

Reaction equation

HRID 1795822 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[CH2:6][N:7]1[C:13](=[O:14])[C:12]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[CH3:26])=[CH:16][C:17](Cl)=[N:18][C:11]=2[O:10][CH2:9][CH2:8]1.[O:36]=[C:37]1[CH2:41][CH2:40][CH2:39][N:38]1[CH:42]1[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1>>[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[CH2:6][N:7]1[C:13](=[O:14])[C:12]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[CH3:26])=[CH:16][C:17]([N:45]3[CH2:44][CH2:43][CH:42]([N:38]4[CH2:39][CH2:40][CH2:41][C:37]4=[O:36])[CH2:47][CH2:46]3)=[N:18][C:11]=2[O:10][CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 183142501-(Piperidin-4-yl)pyrrolidin-2-oneHCID 22179322HCID 22179322, compound

Product 1

HCID 22179328HCID 22179328, compoundYield 8%

Procedure

In a similar manner to Example 1, 4-[3,5-bis(trifluoromethyl)benzyl]-8-chloro-6-(2-methylphenyl)-5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (51.5 mg) was reacted with 4-(2-oxopyrrolidine-1-yl)piperidine (50.5 mg) to obtain 4-[3,5-bis(trifluoromethyl)benzyl]-6-(2-methylphenyl)-8-[4-(2-oxopyrrolidine-1-yl)piperidine-1-yl]-5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.2 mg, 8%).

Sources & evidence

ORD record
ord-8305c13297184335be6e1b92217e9980
Source dataset
uspto-grants-2006_04
Patent number
US07030107B2

Reaction notes

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