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HRID1795827

反应详情

EQUATION

反应方程式

HRID 1795827 的结构方程式

REACTANTS

反应物

2
反应SMILES：OB(O)c1ccc(F)cc1
HCID285645

4-Fluorophenylboronic acid

C6H6BFO2

反应SMILES：O=C1c2c(I)ccnc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
HCID11478095

未命名化合物

PRODUCTS

产物

1
反应SMILES：O=C1c2c(-c3ccc(F)cc3)ccnc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1
HCID22179354

未命名化合物

收率 100.7%

PROCEDURE

实验过程

In a similar manner to Reference Example 4, 5-[3,5-bis(trifluoromethyl)benzyl]-7-iodo-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (300 mg) was reacted with 4-fluorophenylboronic acid (143 mg) to obtain 5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (284 mg, 100%).