HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylphenyl boronic acid → 2-Chloro-4-(2-methylphenyl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| Reactant | 2-Chloro-4-iodonicotinic acid | HCID 17750174 | — |
| Product | 2-Chloro-4-(2-methylphenyl)nicotinic acid | HCID 22179352 | 90% |
Reaction Steps
In a similar manner to Reference Example 4, 2-chloro-4-iodonicotinic acid (Compound of Reference Example 1; 5.67 g) was reacted with 2-methylphenylboronic acid (3.00 g) to obtain 2-chloro-4-(2-methylphenyl)nicotinic acid (4.44 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030107B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-470f03ff10d444899b9d28a2d8048d82 |
| Source note | uspto-grants-2006_04 |