Water → 4-Benzyloxy-2-fluoro-1-nitrobenzene

Participants

Reaction Steps

A solution of 3-fluoro-4-nitrophenol (25 g; 0.159 mol) in DMF (600 ml) under argon was treated at room temperature with Na2CO3 (33.7 g; 0.318 mol). The mixture was stirred and treated dropwise with benzyl bromide (32.6 g; 0.19 mol). Stirring was continued for 3 days when the mixture was poured into water and extracted with Et2O. The organic phase was washed with water, brine and dried over MgSO4. Evaporation gave 4-benzyloxy-2-fluoronitrobenzene as a yellow solid (38 g).

Provenance & Evidence