Water → HCID 22180710, compound

Participants

Reaction Steps

A solution of 5-benzyloxy-2-amino-1H-indole-3-carbonitrile (2.96 g; 11.25 mmol) in DMF (20 ml) under argon was treated at room temperature with Cs2CO3 (4.4 g; 13.5 mmol). The mixture was stirred and treated dropwise with methyl iodide (0.84 ml; 13.48 mmol). Stirring was continued for 1 hour when the mixture was poured into water. The precipitate was filtered, washed with water and dried to give 5-benzyloxy-2-amino-1-methyl-1H-indole-3-carbonitrile as a beige solid (2.77 g).

Provenance & Evidence