HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoacetamide → HCID 22180707, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoacetamide | HCID 3727 | — |
| Reactant | HCID 22180710 | HCID 22180710 | — |
| Solvent | Ethyl ether methylene chloride | HCID 21881112 | — |
| Product | HCID 22180707 | HCID 22180707 | — |
| Product | HCID 22180718 | HCID 22180718 | — |
Reaction Steps
Using the general method of selective N-alkylation described for 5-benzyloxy-2-amino-1-methyl-1H-indole-3-carbonitrile in Example 25, using iodoacetamide (222 mg; 1.2 mmol), 5-benzyloxy-1-carbamoylmethyl-2-amino-1H-indole-3-carbonitrile (163 mg) was obtained as a white solid from 5-benzyloxy-2-amino-1H-indole-3-carbonitrile (263 mg; 1.0 mmol) after trituration with Et2O/CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030123B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-34e2c6004c0f425395a2bc37569ae3b3 |
| Source note | uspto-grants-2006_04 |