Sodium Thiosulfate → HCID 22180717, compound

Participants

Reaction Steps

A solution of 5-(3,4,5-trimethoxyphenoxy)-2-amino-1H-indole-3-carbonitrile (Example 11) (50 mg; 0.147 mmol) in CH2Cl2 (1.0 ml) was treated with trimethyl silyl iodide (30 ul; 0.2 mmol) and the mixture was stirred at room temperature overnight. The mixture was treated with aqueous Na2S2O3 (0.5 M), the CH2Cl2 evaporated and the mixture extracted with EtOAc. The organic phase was washed with water, brine and dried over MgSO4. Evaporation gave 5-(3,5-dimethoxy-4-hydroxy-phenoxy)-2-amino-1H-indole-3-carbonitrile (50 mg).

Provenance & Evidence