Sodium Hydroxide → HCID 22180091, compound

HRID 1795886Notes

Reaction equation

HRID 1795886 reaction equation
[N+:1]([C:4]1[C:5](F)=[C:6]([F:14])[C:7]([F:13])=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10])([O-:3])=[O:2].[OH-:16].[Na+]>>[F:13][C:7]1[C:6]([F:14])=[C:5]([OH:16])[C:4]([N+:1]([O-:3])=[O:2])=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 158712412,3,4-Trifluoro-5-nitrobenzoic acid

Product 1

HCID 22180091HCID 22180091, compound

Procedure

The solid 5-nitro-2,3,4-trifluorobenzoic acid (1.00 g, 0.00452 mol) was dissolved in 10 wt. % aqueous sodium hydroxide solution. The mixture was clear deep orange. After standing under ambient conditions for several minutes, the mixture was quenched with concentrated aqueous hydrochloric acid until strongly acidic (pH 0). A white solid precipitated which was isolated by vacuum filtration and dried with suction to afford 0.40 g of an off-white solid. This solid was recrystallized from chloroform (20 ml) to afford 0.22 g of an off-white crystalline powder; 22% yield; MS (APCl−) 218 (M−1, 100).

Workup

  1. waitAfter standing under ambient conditions for several minutes
  2. customthe mixture was quenched with concentrated aqueous hydrochloric acid until strongly acidic (pH 0)
  3. customA white solid precipitated which
  4. customwas isolated by vacuum filtration
  5. customdried with suction

Sources & evidence

ORD record
ord-46c009a970794e5fb50106e73faf0b5d
Source dataset
uspto-grants-2006_04
Patent number
US07030119B1

Reaction notes

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