Ammonium formate → HCID 9945392, compound

Participants

Reaction Steps

Under argon, to a solution of 5-(2-allyloxymethyl-6,7-dimethoxy-benzofuran-4-ylmethyl)-pyrimidine-2,4-diamine (610 mg, 1.64 mmol) in ACN was added Pd(PPh3)4 complex (571 mg, 0.424 mmol) and ammonium formate (519 mg, 8.23 mmol). The reaction mixture was stirred at reflux for 2 h. Then the reaction was quenched with 1N HCl, the impurities were extracted with ethyl acetate and the solution neutralised with Na2CO3 to pH=7 and saturated with NaOAc. The compound was extracted with ACN dried over MgSO4 and the solvent evaporated to give [4-(2,4-diamino-pyrimidin-5-ylmethyl)-6,7-dimethoxy-benzofuran-2-yl]-methanol (497 mg, 84%) as a yellow solid.

Provenance & Evidence