2-Amino-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one → 3-Bromo-5-chloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-2-thiophenesulfonamide

HRID 1795933Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1795933
[NH2:1][C:2]1[S:3][C:4]2[C:10](=[O:11])[CH2:9][C:8]([CH3:13])([CH3:12])[CH2:7][C:5]=2[N:6]=1.[Br:14][C:15]1[CH:19]=[C:18]([Cl:20])[S:17][C:16]=1[S:21](Cl)(=[O:23])=[O:22]>>[Br:14][C:15]1[CH:19]=[C:18]([Cl:20])[S:17][C:16]=1[S:21]([NH:1][C:2]1[S:3][C:4]2[C:10](=[O:11])[CH2:9][C:8]([CH3:13])([CH3:12])[CH2:7][C:5]=2[N:6]=1)(=[O:23])=[O:22]

Komponenten

3

Edukt 2

HCID 5878742-Amino-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-oneHCID 27374003-Bromo-5-chlorothiophene-2-sulfonyl chloride

Produkt 1

HCID 102262143-Bromo-5-chloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-2-thiophenesulfonamide

Versuchsvorschrift

The title compound was prepared from 2-amino-5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one (53 mg) and 3-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic method to give a white solid (62.2 mg) with purity >90%: MS (pos) m/z 455.2, 457.2.

Quellen und Nachweise

ORD-Eintrag
ord-cced612832b448b1bdb2e9ddfbb67988
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030135B2

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