Hydrochloric Acid → HCID 131725697, compound

Participants

Reaction Steps

A mixture of {3-[[(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-cyclopropyl-methyl]-(4-methyl-benzoyl)-amino]-propyl}-carbamic acid tert-butyl ester (0.24 g, 0.39 mmol) and 4 N HCl in dioxane (10 mL, 16 mmol) in Et2O (10 mL) was stirred at rt for two days. After concentration, the residue was diluted with water, washed with Et2O twice and lyophilized to obtain the title compound (0.14 g, 66%): 13C NMR (D2O) δ 174.1, 155.5, 148.4, 141.0, 136.3, 132.1, 129.7, 129.5, 128.9, 127.7, 126.1, 117.7, 117.2, 111.0, 108.8, 71.7, 70.9, 60.4, 43.4, 42.4, 36.9, 28.1, 20.7, 13.3; MS (ESI+) 504.17, 506.25 (M++H).

Provenance & Evidence