HCID 86759982, compound → HCID 69591774, compound

Participants

Reaction Steps

Ethyl magnesium bromide (1 M, 0.77 ml, 0.77 mmol) was added dropwise to a −78° C. solution of 3-benzyl-2-formyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-5-carboxylic acid methyl ester (0.12 g, 0.39 mmol) in CH2Cl2 (6.0 mL) over 45 min. The reaction mixture was stirred at −78° for 30 min, quenched with saturated NH4Cl (10 mL) and warmed to room temperature. The reaction mixture was extracted with CHCl3 (3×25 mL), dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel eluting with 1/1 hexane/EtOAc to afford the title compound (0.070 g, 50%) as a solid: MS (ESI+) 342 (M++H).

Provenance & Evidence