Triethylamine → HCID 87902786, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonyl chloride (0.024 ml, 0.31 mmol) was added to a 0° C. solution of 3-benzyl-2-(1-hydroxy-propyl)-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-5-carboxylic acid methyl ester (0.007, 0.21 mmol) and triethylamine (0.052 mL, 0.37 mmol) in CH2Cl2 (1.0 mL) and the mixture was stirred at 0° C. for 30 min. The reaction mixture was then quenched with saturated NaHCO3 (3.0 mL), extracted with EtOAc (3×3 ml). The combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo to afford the title compound (0.043 g, 50%) which was used without further purification: MS (ESI+) 420 (M++H).

Provenance & Evidence