Ether hydrochloride → HCID 137242004, compound

HRID 1795984Notes

Reaction equation

HRID 1795984 reaction equation
C(OC(=O)[NH:7][CH:8]([C:11]1[NH:16][C:15](=[O:17])[C:14]2=[CH:18][CH:19]=[CH:20][N:13]2[N:12]=1)[CH2:9][CH3:10])(C)(C)C.[ClH:22].C(OCC)C>CO>[ClH:22].[NH2:7][CH:8]([C:11]1[NH:16][C:15](=[O:17])[C:14]2=[CH:18][CH:19]=[CH:20][N:13]2[N:12]=1)[CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 136435893HCID 136435893, compound

Product 1

HCID 137242004HCID 137242004, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of [1-(4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid tert-butyl ester (10 mg, 0.034 mmol) in absolute methanol (0.5 mL) was treated with 2 N HCl/diethyl ether (2 mL) and the mixture stirred at room temperature overnight. The resulting white suspension was concentrated under vacuum and the solid residue triturated with diethyl ether and dried under vacuum to give the title compound (6 mg, 77%) as white powder: 1H NMR (DMSO-d6) δ 1.08 (t, 3H, J=7.15 Hz), 2.02 (m, 1H), 2.11 (m, 1H), 4.20 (s, 1H), 6.60 (s, 1H), 7.03 (s, 1H), 7.54 (s, 1H).

Workup

  1. concentrationThe resulting white suspension was concentrated under vacuum
  2. customthe solid residue triturated with diethyl ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-d4b480cc113444618417e2dd6824374a
Source dataset
uspto-grants-2006_04
Patent number
US07030118B2

Reaction notes

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