Sodium triacetoxyborohydride → HCID 69591886, compound

Participants

Reaction Conditions

Reaction Steps

(1,1-Dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester (19 mg, 0.564 mmol) and 2-(1-amino-propyl)-3-benzyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (Example 26, 120 mg, 0.376 mmol) were stirred in CH3OH (10 mL) for 1 h at 25° C. The mixture was then treated with NaBH(OAc)3 (119 mg, 0.564 mmol) and stirred for 12 h at 25° C. The mixture was concentrated under vacuum and purified by preparative HPLC using a YMC S10 ODS 30×100 mm column affording the desired material (100 mg, 57%) as a colorless oil: 13C NMR (CDCl3 100 MHz) δ 161.54, 154.93, 154.42, 144.72, 135.84, 129.53, 128.58, 127.27, 121.99, 117.28, 114.95, 111.94, 110.48, 79.81, 58.05, 51.12, 44.61, 43.07, 35.91, 28.17, 27.07, 26.53, 8.55; LC/MS (ESI+) 468 (M++H).

Provenance & Evidence