Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 9947245, compound

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Reaction Steps

2-(4-Chloropyridin-2-yl)benzonitrile (65 mg, 0.3 mmol) was coupled with 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (0.6 mmol) as described in Example 1 to give 2-[4-(7-trifluoromethyl-imidazo[1,2-α]pyrimidin-3-yl)pyridin-2-yl]benzonitrile (15 mg) as a white solid: δH (400 MHz, DMSO) 7.62 (1H, d, J 7.0), 7.69 (1H, m), 7.88 (1H, m), 7.93 (1H, dd, J 5 and 2), 8.04 (2H, m), 8.27 (1H, d, J 1), 8.60 (1H, s), 8.92 (1H, dd, J 5 and 1), 9.60 (1H, d, J 8); m/z (ES+) 366 (M++H).

Provenance & Evidence