2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine

Participants

Reaction Steps

2,4-Dichloropyrimidine (317 mg, 2.13 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.4 mmol) by the method of Example 1 to give 3-(2-chloropyrimidin-4-yl)-7-trifluoromethylimidazo[1,2-α]pyrimidine (167 mg) as a white solid: δH (400 MHz, DMSO) 7.91 (1H, d, J 7), 8.25 (1H, d, J 5), 8.83 (1H, d, J 5), 9.17 (1H, s), 10.22 (1H, d, J 7); m/z (ES+) 300, 302 (M++H).

Provenance & Evidence