2-Bromothiazole → HCID 9835150, compound

HRID 1796013Notes

Reaction equation

Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.C([Sn](CCCC)(CCCC)[C:12]1[N:16]2[CH:17]=[CH:18][C:19]([C:21]([F:24])([F:23])[F:22])=[N:20][C:15]2=[N:14][CH:13]=1)CCC>>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[C:12]1[N:16]2[CH:17]=[CH:18][C:19]([C:21]([F:22])([F:23])[F:24])=[N:20][C:15]2=[N:14][CH:13]=1

Participants

Reactant 2

HCID 764302-Bromothiazole

HCID 11294484Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)-

Product 1

HCID 9835150HCID 9835150, compoundYield 33.3%

Procedure

2-Bromothiazole (341 μl, 3.78 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.8 mmol) by the method of Example 1 to give 3-(thiazol-2-yl)-7-trifluoromethyl-imidazo[1,2-α]pyrimidine (162 mg) as an off-white solid: δH (400 MHz, CDCl3) 7.40 (2H, dd, J 4 and 3), 7.93 (1H, d, J 3), 8.48 (1H, s), 10.22 (1H, d, J 8); m/z (ES+) 271 (M++H).

Sources & evidence

ORD record: ord-fe9c524f048e4ce4a8d078f4a55515d4
Source dataset: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07030128B2

Reaction notes

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