6-Chloro-3-pyridinecarbonitrile → HCID 9943829, compound

Participants

Reaction Steps

6-Chloronicotinonitrile (295 mg, 2.13 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.4 mmol) by the method of Example 1 to give 6-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)nicotinonitrile (142 mg) as a white solid: δH (400 MHz, DMSO) 7.79 (1H, d, J 7), 8.35 (1H, m), 8.43 (1H, m), 9.06 (1H, s), 9.14 (1H, s), 10.41 (1H, d, J 7); m/z (ES+) 290 (M++H).

Provenance & Evidence