2-Chloropyridine → HCID 9921462, compound

Participants

Reaction Steps

2-Chloropyridine (361 μl, 3.78 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.89 mmol) by the method of Example 1 to give 3-(pyridin-2-yl)-7-trifluoromethyl-imidazo[1,2-α]pyrimidine (134 mg) as a white solid: δH (400 MHz, CDCl3) 7.24-7.30 (1H, m), 7.33 (1H, d, J 7.0), 7.82-7.84 (2H, m), 8.51 (1H, s), 8.68-8.70 (1H, m), 10.54 (1H, d, J 7.0); m/z (ES+) 265 (M++H).

Provenance & Evidence