反应详情

2-Bromo-6-(pyrrolidin-1-yl)pyridine (481 mg, 2.1 mmol) (prepared by the method of T. Sammakia et al., J. Org. Chem., 1999, 64(13), 4652-4664) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.4 mmol) by the method of Example 1 to give 3-[6-(pyrrolidin-1-yl)pyridin-2-yl]-7-trifluoromethylimidazo[1,2-α]pyrimidine (125 mg) as a white solid: δH (360 MHz, DMSO) 2.02 (4H, t, J 6.5), 3.51 (4H, bs), 6.43 (1H, d, J 8.4), 7.27 (1H, d, J 7.7), 7.63 (1H, t, J 7.9), 7.71 (1H, d, J 7.4), 8.72 (1H, s), 10.51 (1H, d, J 7.4); m/z (ES+) 334 (M++H).