2-Chloro-6-(trifluoromethyl)pyridine → HCID 9945466, compound

Participants

Reaction Steps

2-Chloro-6-trifluoromethylpyridine (385 mg, 2.1 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.4 mmol) by the method of Example 1 to give 7-trifluoromethyl-3-(6-trifluoromethyl-pyridin-2-yl)imidazo[1,2-α]pyrimidine (65 mg) as a white solid: δH (360 MHz, DMSO) 7.89 (2H, d, J 7.4), 8.27 (1H, t, J 7.9), 8.46 (1H, d, J 7.4), 9.01 (1H, s), 10.26 (1H, d, J 7.4); m/z (ES+) 333 (M++H).

Provenance & Evidence